GSTTP1


GSTTP1: The Gateway to Understanding Cancer and Disease

What is GSTTP1?

GSTTP1, short for glutathione S-transferase pi 1, is a protein encoded by the GSTT1 gene. It belongs to a family of detoxification enzymes known as glutathione S-transferases, which play a crucial role in protecting cells from harmful substances. GSTTP1 specifically neutralizes toxins by attaching them to a small molecule called glutathione, rendering them inert and enabling their excretion from the body.

Role in Associated Diseases

Cancer: GSTTP1 is widely studied in relation to cancer susceptibility and prognosis. It has been found to be significantly reduced or absent in certain types of cancers, including:

  • Lung cancer
  • Prostate cancer
  • Bladder cancer
  • Head and neck cancer
  • Leukemia

Neurological Disorders: GSTTP1 has been implicated in the development and progression of neurodegenerative diseases, such as:

  • Alzheimer's disease
  • Parkinson's disease
  • Multiple sclerosis

Other Associated Diseases: GSTTP1 has also been linked to various other diseases, including:

  • Atherosclerosis
  • Rheumatoid arthritis
  • Asthma

Did you Know ?

Approximately 15-20% of the human population has a genetic deletion of the GSTT1 gene, resulting in a complete lack of GSTTP1 protein. This genetic variation is associated with an increased risk of developing certain cancers, particularly lung cancer.



Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.