GSTT2
Description
The GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)) is a protein-coding gene located on chromosome 22.
Glutathione S-transferase theta-2 (GSTT2) is an enzyme encoded by the GSTT2 gene in humans. GSTs are a large family of proteins that catalyze the attachment of reduced glutathione to various electrophilic and hydrophobic compounds. Human GSTs are categorized into five main classes: Alpha, Mu, Pi, Theta, and Zeta. GSTT1 and GSTT2, both members of the theta class, share 55% of their amino acid sequence and are thought to be crucial in human carcinogenesis. The theta genes have a similar structure, consisting of five exons with identical exon/intron boundaries.
GSTT2 catalyzes the conjugation of reduced glutathione to a wide range of hydrophobic electrophiles, both from outside the body (exogenous) and from within the body (endogenous). It also has sulfatase activity.
GSTT2 is also known as -.
Associated Diseases
- colon adenoma
- cancer
- Charcot-Marie-Tooth disease type 1A
- schizophrenia
- Charcot-Marie-Tooth disease
- Norum disease
- Huntington disease
- type 2 diabetes mellitus
- breast angiosarcoma
- urinary bladder carcinoma
- Charcot-Marie-Tooth disease, axonal, type 2FF
