GSTO1
Description
The GSTO1 (glutathione S-transferase omega 1) is a protein-coding gene located on chromosome 10.
GSTO1 encodes a member of the theta class glutathione S-transferase-like (GSTTL) protein family. The encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis. It has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism.
GSTO1 exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. It has S-(phenacyl)glutathione reductase activity and also glutathione S-transferase activity. It participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
GSTO1 is also known as GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R.
Associated Diseases
- Parkinson disease
- Alzheimer disease
- multiple sclerosis
- lysosomal storage disease
- nonpapillary renal cell carcinoma
- cancer
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- hemoglobin D disease
- delta-beta-thalassemia
- dominant beta-thalassemia
- hemoglobin C-beta-thalassemia syndrome
- hemoglobin E-beta-thalassemia syndrome
- alpha-thalassemia-myelodysplastic syndrome
