GSTM3
Description
The GSTM3 (glutathione S-transferase mu 3) is a protein-coding gene located on chromosome 1.
Glutathione S-transferase M3 (brain), also known as GSTM2, is an enzyme encoded by the GSTM99 gene in humans. It belongs to the mu class of glutathione S-transferases, which are involved in the detoxification of electrophilic compounds like carcinogens, drugs, environmental toxins, and oxidative stress products. These enzymes function by conjugating glutathione to the electrophilic compounds. The mu class genes are located in a cluster on chromosome 1p13.3 and exhibit high polymorphism. These variations can influence individual susceptibility to carcinogens and toxins, as well as drug toxicity and efficacy. Mutations in this mu class gene have been associated with a slight increase in certain cancers, likely due to exposure to environmental toxins.
GSTM3 is also known as GST5, GSTB, GSTM3-3, GSTM3TV2, GTM3, hGSTM3-3.
