GSTA4
Description
The GSTA4 (glutathione S-transferase alpha 4) is a protein-coding gene located on chromosome 6.
GSTA4 is an enzyme encoded by the GSTA4 gene in humans. It belongs to the alpha class of glutathione S-transferases, which are involved in cellular defense against toxic, carcinogenic, and pharmacologically active compounds. GSTA4 specifically detoxifies lipid peroxidation products, particularly reactive carbonyl compounds like alk-2-enals. It is highly effective in conjugating reduced glutathione to 4-hydroxynonenal, a key product of arachidonic acid degradation and a marker of oxidative damage. Reduced expression of GSTA4 may contribute to the development of degenerative diseases like Parkinson's disease, Alzheimer's disease, cataracts, and atherosclerosis. Its expression is significantly decreased in burn and trauma victims.
GSTA4 is also known as GSTA4-4, GTA4.
Associated Diseases
- Parkinson disease
- Alzheimer disease
- multiple sclerosis
- lysosomal storage disease
- substance abuse
- glioblastoma
