GSTA2
Description
The GSTA2 (glutathione S-transferase alpha 2) is a protein-coding gene located on chromosome 6.
Glutathione S-transferase A2 is an enzyme encoded by the GSTA2 gene in humans. It belongs to the alpha class of glutathione S-transferases, which are involved in detoxification by conjugating glutathione to electrophilic compounds. These compounds include carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. The GSTA2 gene is highly polymorphic, meaning there are many variations in its sequence. These variations can influence an individual's susceptibility to carcinogens and toxins, as well as the toxicity and efficacy of certain drugs. The alpha class genes, including GSTA2, are clustered on chromosome 6 and are highly expressed in the liver. In addition to metabolizing bilirubin and some anti-cancer drugs, the alpha class enzymes also exhibit glutathione peroxidase activity, protecting cells from reactive oxygen species and the products of peroxidation.
GSTA2 is also known as GST2, GSTA2-2, GTA2, GTH2.
