GSPT2

Description

The GSPT2 (G1 to S phase transition 2) is a protein-coding gene located on chromosome X.

GSPT2 encodes the eukaryotic peptide chain release factor GTP-binding subunit ERF3B, an enzyme involved in protein synthesis termination. It is closely related to GSPT1, another GTP-binding protein essential for cell cycle progression. GSPT2 interacts with PABPC1 and plays a role in translation accuracy.

GSPT2, also known as ERF3B, is a GTPase that plays a key role in translation termination. It is part of the eRF1-eRF3-GTP ternary complex which binds to stop codons (UAA, UAG, and UGA) in the ribosome's A-site. GSPT2 mediates the delivery of eRF1 to the stop codon, a process involving GTP hydrolysis and conformational changes. GSPT2 is also involved in nonsense-mediated decay (NMD), a quality control mechanism that eliminates mRNAs containing premature stop codons. In NMD, GSPT2 is part of the transient SURF complex, which recruits UPF1 to stalled ribosomes.

GSPT2 is also known as ERF3B, GST2.

Associated Diseases

• endometrial cancer
• Gorham-Stout disease
• melorheostosis
• laryngotracheoesophageal cleft
• X-linked intellectual disability
• Alzheimer disease
• autosomal dominant cerebellar ataxia