GRP
Description
The GRP (gastrin releasing peptide) is a protein-coding gene located on chromosome 18.
GRP, or Gastrin-releasing peptide, is a multifaceted protein involved in various biological processes. It is best known for its role in the gastrointestinal system, stimulating the release of gastrin and other hormones. However, GRP also plays a part in the perception and transmission of itch, the regulation of food intake, and the modulation of memory and fear responses. In the nervous system, GRP interacts with neurons in the amygdala, auditory cortex, and hippocampus, influencing neuronal activity and contributing to both the inhibition and enhancement of specific memory types. Furthermore, GRP directly affects respiratory function by inducing sighing.
GRP, also known as gastrin-releasing peptide, plays a role in various physiological processes, including the stimulation of gastrin and other gastrointestinal hormones, perception of itch, and modulation of fear and memory. It contributes to nonhistaminergic itch sensation, inhibiting learned fear memory in the amygdala and promoting auditory fear memory in the auditory cortex. GRP is involved in regulating food intake, influencing neuronal activity in the hippocampus, and inducing sighing by acting on the pre-Botzinger complex. Evidence for these functions comes from experimental studies and similarity-based annotations.
GRP is also known as BN, GRP-10, preproGRP, proGRP.
