GRM8
Description
The GRM8 (glutamate metabotropic receptor 8) is a protein-coding gene located on chromosome 7.
Metabotropic glutamate receptor 8 is a protein encoded by the GRM8 gene in humans. It is one of several receptors for the neurotransmitter glutamate, which is crucial for brain function. Glutamate receptors are classified into ionotropic and metabotropic types, with metabotropic receptors further categorized into three groups. GRM8 belongs to Group III, which is linked to the inhibition of the cyclic AMP cascade. This group of receptors differs from the other two in terms of their agonist selectivity. While alternative splice variants of GRM8 have been identified, their complete structures are yet to be determined. Known ligands for GRM8 include the agonist (S)-3,4-DCPG and the positive allosteric modulator AZ12216052.
G-protein coupled receptor for glutamate. When a ligand binds to the receptor, it undergoes a conformational change that activates signaling through guanine nucleotide-binding proteins (G proteins). This signaling pathway ultimately inhibits the activity of adenylate cyclase.
GRM8 is also known as GLUR8, GPRC1H, MGLUR8, mGlu8.
