GRM2
Description
The GRM2 (glutamate metabotropic receptor 2) is a protein-coding gene located on chromosome 3.
Metabotropic glutamate receptor 2 (mGluR2) is a protein encoded by the GRM2 gene in humans. It's a G protein-coupled receptor (GPCR) that interacts with the Gi alpha subunit. mGluR2 acts as an autoreceptor for glutamate, inhibiting the release of neurotransmitters from the presynaptic terminal of glutamatergic neurons when activated. The GRM2 gene resides on chromosome 3 and encodes at least three protein-coding isoforms and numerous non-coding isoforms. The mGluR2 protein is a seven-pass transmembrane protein. It is exclusively expressed in the brain, specifically in neurons and astrocytes, with its primary localization at the presynaptic terminal and also present at the postsynaptic terminal. Metabotropic glutamate receptors are categorized into three groups based on sequence homology, signaling pathways, and pharmacological properties: Group I (GRM1 and GRM5), Group II (mGluR2 and GRM3), and Group III (GRM4, GRM6, GRM7, and GRM8). Group I activates phospholipase C, while Group II and III have different signaling pathways.
GRM2 is also known as GLUR2, GPRC1B, MGLUR2, mGlu2.
Associated Diseases
- schizophrenia
- thyroid gland adenocarcinoma
- major depressive disorder
- low grade glioma
- depressive disorder
- asthma
- bipolar disorder
