GRIN2D
Description
The GRIN2D (glutamate ionotropic receptor NMDA type subunit 2D) is a protein-coding gene located on chromosome 19.
The GRIN2D gene encodes for the Glutamate [NMDA] receptor subunit epsilon-4 protein in humans. NMDA receptors are a type of ionotropic glutamate receptor involved in long-term potentiation, a process crucial for memory and learning. These receptors are composed of the NMDAR1 subunit (GRIN1) and one or more of the four NMDAR2 subunits, including GRIN2D. GRIN2D has been shown to interact with Interleukin 16.
GRIN2D is a subunit of NMDA receptors, which are heterotetrameric, ligand-gated ion channels. These channels exhibit high calcium permeability and are sensitive to magnesium in a voltage-dependent manner. To activate the channel, glutamate must bind to the epsilon subunit, glycine to the zeta subunit, and the membrane must depolarize to remove Mg(2+) inhibition. The subunit composition affects glutamate sensitivity and channel kinetics.
GRIN2D is also known as DEE46, EB11, EIEE46, GluN2D, NMDAR2D, NR2D.
