GRIK4

Description

The GRIK4 (glutamate ionotropic receptor kainate type subunit 4) is a protein-coding gene located on chromosome 11.

GRIK4 is a kainate receptor subtype encoded by the GRIK4 gene. It forms functional ion channels with subunits from related genes. GRIK4 plays a role in brain function, with variations linked to antidepressant response, bipolar disorder, and neuronal cell death. The gene has undergone accelerated evolution in primates, particularly humans, suggesting its importance in nervous system development.

GRIK4 is a receptor for glutamate, a major excitatory neurotransmitter in the central nervous system. Glutamate's actions are mediated by various receptors, categorized by their selective agonists.

GRIK4 is also known as EAA1, GRIK, GluK4, GluK4-2, KA1.

Associated Diseases

• migraine disorder
• alcohol dependence
• Lennox-Gastaut syndrome
• glaucoma
• bipolar disorder
• type 2 diabetes mellitus