GRHL1
Description
The GRHL1 (grainyhead like transcription factor 1) is a protein-coding gene located on chromosome 2.
GRHL1 is a gene that encodes a transcription factor involved in epithelial development. It binds to a specific DNA sequence and plays a role in regulating the expression of other genes, particularly those involved in skin development and hair growth. It may also be involved in regulating glucose levels and insulin signaling.
GRHL1 is a transcription factor involved in epithelial development. It binds directly to the consensus DNA sequence 5'-AACCGGTT-3' and acts as an important regulator of DSG1 in hair anchorage and epidermal differentiation. GRHL1 also plays a role in maintaining the skin barrier. Although it does not genetically interact or functionally cooperate with GRHL3, it may contribute to regulating glucose homeostasis and insulin signaling. It functions as a transcription activator and may act as a repressor in tissues where both isoform 1 and isoform 2 are expressed.
GRHL1 is also known as LBP32, MGR, NH32, TFCP2L2.
Associated Diseases
- type 2 diabetes mellitus
- hypotrichosis simplex
- erythrokeratodermia variabilis
- Graham Little-Piccardi-Lassueur syndrome
- hypotrichosis 4
- wooly hair, autosomal recessive 3
- monilethrix
- Clouston syndrome
- pure hair and nail ectodermal dysplasia
- uncombable hair syndrome
