GREM1

Description

The GREM1 gene, also known as Gremlin 1, plays a crucial role in regulating bone and cartilage development. It encodes a protein that acts as an antagonist of bone morphogenetic proteins (BMPs), a family of signaling molecules essential for skeletal growth and differentiation. GREM1 inhibits BMP signaling, thereby controlling the timing and extent of bone and cartilage formation. This gene is expressed in various tissues, including the developing skeleton, cartilage, and tendons, where it contributes to the precise formation and maintenance of these structures.

Associated Diseases

• Achondroplasia
• Osteogenesis imperfecta
• Fibrodysplasia ossificans progressiva
• Cartilage hair hypoplasia
• Multiple epiphyseal dysplasia

Did you know?

GREM1 is implicated in the development of polydactyly, a condition characterized by having extra fingers or toes.