GRB7

Description

The GRB7 (growth factor receptor bound protein 7) is a protein-coding gene located on chromosome 17.

GRB7 (Growth factor receptor-bound protein 7) is a protein encoded by the GRB7 gene in humans. It belongs to a family of adaptor proteins that interact with receptor tyrosine kinases and signaling molecules. GRB7 interacts with epidermal growth factor receptor (EGFR) and ephrin receptors, playing a role in integrin signaling and cell migration by binding to focal adhesion kinase (FAK). Alternative splicing produces multiple transcript variants encoding different isoforms. GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and links them to the Ras proto-oncogene. It is located on chromosome 17, near the ERBB2 (HER2/neu) proto-oncogene, and both genes are often co-amplified in breast cancers. GRB7 is overexpressed in testicular germ cell tumors, esophageal cancers, and gastric cancers, suggesting a role in cell migration.

GRB7 is an adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates downstream signaling. It promotes activation of downstream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3, and activates HRAS. GRB7 plays a role in signal transduction in response to EGF, as well as in the regulation of cell proliferation and cell migration. It is also involved in the assembly and stability of RNA stress granules. When not phosphorylated, GRB7 binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.

GRB7 is also known as -.

Associated Diseases

WES Whole Exome Sequencing