GPSM1
Description
The GPSM1 (G protein signaling modulator 1) is a protein-coding gene located on chromosome 9.
GPSM1, or G-protein-signaling modulator 1, is a protein encoded by the GPSM1 gene in humans. G proteins, involved in intracellular signaling, are activated by G protein-coupled receptors.
GPSM1 acts as a receptor-independent activator of heterotrimeric G-protein signaling. It keeps the G(i/o) alpha subunit in its GDP-bound state, effectively uncoupling G-protein signaling from G protein-coupled receptors. This protein plays a role in controlling spindle orientation and asymmetric cell fate in cerebral cortical progenitors. It may also be involved in macroautophagy in intestinal cells and potentially contribute to drug addiction.
GPSM1 is also known as AGS3.
