GPRC5C
Description
The GPRC5C (G protein-coupled receptor class C group 5 member C) is a protein-coding gene located on chromosome 17.
GPRC5C (G-protein coupled receptor family C group 5 member C) is a human protein encoded by the GPRC5C gene. It belongs to the type 3 G protein-coupled receptor family, characterized by a 7-transmembrane domain motif. While its specific function is unknown, it may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been identified for this gene.
GPRC5C, a retinoic acid-inducible G-protein coupled receptor, suggests a potential connection between retinoid signaling and G-protein signaling pathways.
GPRC5C is also known as RAIG-3, RAIG3.
Associated Diseases
- hemoglobin E-beta-thalassemia syndrome
- dehydrated hereditary stomatocytosis
- hemoglobin D disease
- Rh deficiency syndrome
- hemolytic anemia due to erythrocyte adenosine deaminase overproduction
- alpha-thalassemia-myelodysplastic syndrome
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome
- microcytic anemia with liver iron overload
- cryohydrocytosis
- familial pseudohyperkalemia
- severe congenital hypochromic anemia with ringed sideroblasts
- IRIDA syndrome
- beta-thalassemia-X-linked thrombocytopenia syndrome
- elliptocytosis 2
