GPR98
The Mysterious GPR98 Gene: Unraveling Its Role in Disease and Beyond
Description
GPR98, also known as G protein-coupled receptor 98, is a gene that encodes a protein found on the surface of cells. This protein acts as a receptor, receiving signals from outside the cell and initiating a chain of events within the cell. GPR98 plays a crucial role in various biological processes, including cell growth, differentiation, and metabolism. Recent research has uncovered its potential involvement in diseases ranging from cancer to metabolic disorders.
Associated Diseases
Cancer: GPR98 has been linked to the development and progression of several types of cancer, including breast, lung, and colorectal cancer. Overexpression of GPR98 in cancer cells has been associated with increased cell proliferation, invasion, and metastasis.
Metabolic Disorders: GPR98 is involved in regulating glucose metabolism and insulin sensitivity. Alterations in GPR98 expression or function have been linked to obesity, type 2 diabetes, and non-alcoholic fatty liver disease.
Neurological Disorders: Recent studies have suggested that GPR98 may play a role in the pathogenesis of neurological disorders such as Alzheimer's disease and Parkinson's disease. Dysregulation of GPR98 signaling has been associated with neuronal damage and cognitive impairment.
Did you Know ?
According to a study published in the journal "Nature Genetics," a single nucleotide polymorphism (SNP) within the GPR98 gene has been found to significantly increase the risk of obesity in certain populations. This SNP alters the structure of the GPR98 protein, potentially affecting its function in regulating metabolism.
