GPR75
Description
The GPR75 (G protein-coupled receptor 75) is a protein-coding gene located on chromosome 2.
GPR75, also known as Probable G-protein coupled receptor 75, is a protein encoded by the GPR75 gene in humans. It belongs to the G protein-coupled receptor family, which are cell surface receptors that activate guanine-nucleotide binding proteins upon ligand binding. GPR75 is currently classified as an orphan GPCR, meaning its specific ligand is still being investigated. Studies have shown that the chemokine CCL5 (RANTES) can stimulate calcium mobilization and inositol triphosphate formation in cells expressing GPR75. Research in 2021 found that individuals with protein-truncating variants of GPR75 had a lower body weight and reduced odds of obesity. Additionally, GPR75 knockout mice exhibited resistance to weight gain when fed a high-fat diet.
GPR75 is also known as GPRchr2, WI31133.
