GPR65
Description
The GPR65 (G protein-coupled receptor 65) is a protein-coding gene located on chromosome 14.
GPR65, also called TDAG8, is a G protein-coupled receptor (GPCR) primarily found in lymphoid tissues (spleen, lymph nodes, thymus, and leukocytes) and localized to the plasma membrane. While initially reported to bind psychosine, the specific binding of psychosine to GPR65 has been contested. More recently, BTB09089 has been identified as a specific agonist for GPR65. Additionally, GPR65 senses extracellular pH, with higher levels of cAMP observed in neutral to acidic pH (pH 7.0-6.5) in cells expressing GPR65. This pH-sensing effect is reduced or eliminated in cells with mutated GPR65. The presence of psychosine shifts the cAMP increase to a more acidic pH range.
GPR65 acts as a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. It contributes to immune response by maintaining lysosome function and facilitating phagocytosis-mediated clearance of intracellular bacteria. GPR65 may also play a role in activation-induced cell death or differentiation of T-cells.
GPR65 is also known as TDAG8, hTDAG8.
