GPR56
GPR56 Gene: A Regulator of Metabolic and Inflammatory Processes
Description
The GPR56 gene (also known as ADGRG1) encodes a G protein-coupled receptor (GPCR) called GPR56. GPCRs are proteins that transmit signals from outside the cell to the inside, regulating various cellular processes. GPR56 is expressed in various tissues, including the brain, adipose tissue, liver, and immune cells.
Associated Diseases
GPR56 has been implicated in several human diseases, including:
- Obesity: GPR56 is expressed in adipose tissue and is involved in regulating appetite and energy expenditure. Mutations in GPR56 have been linked to obesity and related metabolic disorders.
- Type 2 Diabetes: GPR56 is expressed in the pancreas and is involved in insulin secretion. Dysregulation of GPR56 signaling can contribute to the development of type 2 diabetes.
- Autoimmune Diseases: GPR56 is expressed in immune cells and plays a role in immune regulation. Dysfunctional GPR56 signaling has been associated with autoimmune diseases such as rheumatoid arthritis and lupus.
Did you Know ?
GPR56 has been found to regulate the production of the hormone leptin in adipose tissue. Leptin signals to the brain to suppress appetite and increase energy expenditure. Studies have shown that mice lacking GPR56 have elevated leptin levels and are prone to obesity.
