GPR37L1
Description
The GPR37L1 (G protein-coupled receptor 37 like 1) is a protein-coding gene located on chromosome 1.
Endothelin B receptor-like protein 2 is a protein that in humans is encoded by the GPR37L1 gene.
GPR37L1, also known as Endothelin B receptor-like protein 2, is a G-protein coupled receptor. It has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. GPR37L1 has been suggested to be a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. GPR37L1 participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. It regulates baseline blood pressure in females and protects against cardiovascular stress in males. It mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity. It interacts with the PTCH1 receptor.
GPR37L1 is also known as ET(B)R-LP-2, ETBR-LP-2, ETBRLP2.
Associated Diseases
- ovarian cancer
- metabolic syndrome X
- supravalvular aortic stenosis
- familial atrial fibrillation
- spinocerebellar ataxia type 27
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 10
- hereditary antithrombin deficiency
- familial hyperaldosteronism
- spinocerebellar ataxia type 21
- pseudohyperaldosteronism type 2
- familial hyperaldosteronism type II
