GPR182
GPR182: A Critical G Protein-Coupled Receptor in Health and Disease
Description
GPR182, also known as G protein-coupled receptor 182, is a transmembrane protein that belongs to the G protein-coupled receptor (GPCR) superfamily. GPCRs play crucial roles in cellular signaling by transducing extracellular signals into intracellular responses. GPR182 is expressed in various tissues, including the brain, immune system, and gastrointestinal tract.
GPR182 binds to a diverse range of ligands, including lipids, peptides, and small molecules. Upon ligand binding, GPR182 activates specific G proteins, which in turn modulate various downstream signaling pathways. These pathways regulate cellular processes such as inflammation, pain perception, and glucose metabolism.
Associated Diseases
Dysregulation of GPR182 signaling has been implicated in several diseases, including:
- Alzheimer's disease: GPR182 expression is reduced in the brains of Alzheimer's patients, suggesting its potential role in cognitive impairment.
- Chronic pain: GPR182 antagonists have shown promise in reducing pain in animal models of inflammatory pain.
- Metabolic disorders: GPR182 plays a role in glucose homeostasis and insulin sensitivity, and its dysfunction may contribute to type 2 diabetes and obesity.
- Cancer: GPR182 is expressed in various cancer cells and may be involved in tumor growth and progression.
Did you Know ?
GPR182 is one of the most widely expressed GPCRs in the human brain, highlighting its potential importance in neuropsychiatric diseases.
