GPR135
Description
The GPR135 (G protein-coupled receptor 135) is a protein-coding gene located on chromosome 14.
GPR135, also known as Probable G-protein coupled receptor 135, is a protein encoded by the GPR135 gene in humans.
GPR135 is an orphan receptor, meaning its specific ligand remains unidentified. It exhibits spontaneous activity for beta-arrestin recruitment, suggesting a signaling pathway independent of known ligands. GPR135 displays a reciprocal regulatory interaction with the melatonin receptor MTNR1B, likely mediated by receptor heteromerization. This interaction potentially contributes to the regulation of melatonin signaling.
GPR135 is also known as HUMNPIIY20.
Associated Diseases
- substance abuse
- schizophrenia 15
- Phelan-McDermid syndrome
- Potocki-Lupski syndrome
- Smith-Magenis syndrome
- intellectual developmental disorder, X-linked, syndromic, Pilorge type
- FRAXE intellectual disability
- cancer
