GPER1

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GPR1: Unraveling the Mystery of a Multifaceted Receptor

Description

GPR1, also known as G protein-coupled receptor 1, is a versatile receptor that plays a crucial role in the body's various physiological processes. It belongs to the family of G protein-coupled receptors (GPCRs), which are the largest and most diverse group of cell surface receptors involved in signal transduction.

GPR1 is ubiquitously expressed throughout the body, with high concentrations in the central nervous system, heart, lungs, and immune cells. It is a 352-amino acid protein with a typical seven-transmembrane domain structure.

Associated Diseases

GPR1 has been implicated in a wide range of diseases due to its diverse functions. Dysregulation of GPR1 signaling can lead to:

• Neurological Disorders:
  • Alzheimer's disease
  • Parkinson's disease
  • Schizophrenia
• Cardiovascular Diseases:
  • Myocardial infarction
  • Heart failure
  • Arrhythmias
• Immune Disorders:
  • Rheumatoid arthritis
  • Asthma
  • Sepsis
• Metabolic Disorders:
  • Obesity
  • Diabetes
• Cancer:
  • Melanoma
  • Lung cancer

Did you Know ?

GPR1 is expressed in 90% of human tissues, highlighting its widespread and essential role in cellular communication. This high level of expression indicates its involvement in a multitude of physiological processes.