GPBAR1
Description:
G protein-coupled receptor 1 (GPBAR1) is a member of the G protein-coupled receptor (GPCR) family, which is involved in a wide range of cellular processes. GPBAR1 is expressed in various tissues throughout the body, including the brain, gastrointestinal tract, and immune system. It is activated by the endogenous ligand GPR37, also known as PAFR-like receptor 2 (PLR2).
GPBAR1 has been identified as a key player in several physiological processes, including inflammation, immune function, and neurotransmission. It is thought to play a role in the regulation of inflammatory responses and the maintenance of immune homeostasis. In the brain, GPBAR1 is involved in the modulation of pain perception and anxiety.
Associated Diseases:
Dysregulation of GPBAR1 signaling has been implicated in the development of several diseases, including:
- Autoimmune diseases: GPBAR1 has been found to be downregulated in patients with multiple sclerosis and rheumatoid arthritis. This suggests that GPBAR1 may play a role in the development and progression of these autoimmune diseases.
- Chronic pain: GPBAR1 is expressed in the spinal cord and DRG neurons, where it regulates the transmission of pain signals. Alterations in GPBAR1 expression or function have been linked to chronic pain conditions, such as fibromyalgia and neuropathic pain.
- Neuropsychiatric disorders: GPBAR1 has been implicated in the pathophysiology of several neuropsychiatric disorders, including anxiety, depression, and schizophrenia. It is believed that GPBAR1 may play a role in the regulation of neurotransmitter systems involved in these conditions.
Did you Know ?
- GPBAR1 is one of the most highly expressed GPCRs in the human brain.
