GPAT2

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Description

The GPAT2 (glycerol-3-phosphate acyltransferase 2, mitochondrial) is a protein-coding gene located on chromosome 2.

GPAT2 catalyzes the transfer of an acyl group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, generating lysophosphatidic acid (LPA). This reaction is crucial for the synthesis of triacylglycerol (TAG) and glycerophospholipids. In vitro, GPAT2 can also transfer an acyl group from acyl-ACP to LPA, producing phosphatidic acid (PA). GPAT2 exhibits a preference for arachidonoyl-CoA as the acyl donor. Additionally, GPAT2 plays a role in the primary processing step during piRNA biosynthesis, although the exact mechanisms are unknown and do not involve its acyltransferase activity.

GPAT2 is also known as CT123.

Associated Diseases

• male infertility with teratozoospermia due to single gene mutation
• partial chromosome Y deletion
• spinocerebellar ataxia type 32
• spermatogenic failures 50
• spermatogenic failure 25
• congenital bilateral absence of vas deferens
• isochromosomy Yp
• spermatogenic failure, X-linked, 2
• spermatogenic failure 63
• spermatogenic failure 61
• spermatogenic failure 48
• spermatogenic failure 74
• spermatogenic failure 73
• isochromosomy Yq
• spermatogenic failure, X-linked, 3
• spermatogenic failure 65
• spermatogenic failure 40