GORASP1
Description
The GORASP1 (golgi reassembly stacking protein 1) is a protein-coding gene located on chromosome 3.
GORASP1, also known as GRASP65, is a peripheral membrane protein involved in the formation and maintenance of the Golgi apparatus. It is anchored to the Golgi membrane through myristoylation and plays a crucial role in stacking the Golgi cisternae and linking them into larger ribbons in vertebrate cells. GORASP1 interacts with other Golgi proteins, including GM130 and p115, and is a substrate for caspase-3. Cleavage of GORASP1 during apoptosis contributes to the fragmentation of the Golgi. Several splice variants of this gene have been identified, but their full-length nature is yet to be determined.
GORASP1 is a key structural protein of the Golgi apparatus, playing a role in the formation and maintenance of the Golgi ribbon. It works in conjunction with GORASP2/GRASP55, and while it may be dispensable for the formation of stacks, it is essential for the assembly and membrane stacking of cisternae, as well as the reassembly of Golgi stacks after breakdown during mitosis. Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis. Additionally, GORASP1 mediates the docking of transport vesicles with the Golgi membranes through its interaction with GOLGA2/GM130. Furthermore, it facilitates the unconventional trafficking of core-glycosylated CFTR to the cell membrane in response to ER stress.
GORASP1 is also known as GOLPH5, GRASP65, P65.
