GNL3L
Description
The GNL3L (G protein nucleolar 3 like) is a protein-coding gene located on chromosome X.
GNL3L stabilizes TERF1 telomeric association by preventing its recruitment by PML. It also protects TERF1 from ubiquitination and proteasomal degradation by interfering with TERF1 binding to the FBXO4 E3 ubiquitin ligase. GNL3L is essential for cell proliferation and promotes the transition from metaphase to anaphase by stabilizing TRF1 during mitosis. It further stabilizes MDM2 by preventing its ubiquitination and degradation, potentially impacting TP53 activity. GNL3L is required for normal ribosomal pre-rRNA processing. It binds GTP and interacts with MDM2 in the nucleoplasm, stabilizing MDM2. This interaction indirectly affects TP53 through MDM2. GNL3L interacts with TERF1, likely in the nucleoplasm, and this interaction strengthens during mitosis when the nucleolus is disassembled. This binding may promote TERF1 homodimerization. GNL3L also interacts with TERT.
GNL3L is also known as GNL3B.
