GNA13
Description
The GNA13 (G protein subunit alpha 13) is a protein-coding gene located on chromosome 17.
GNA13 gene encodes the G13 G protein alpha subunit, one of the four classes of heterotrimeric G protein alpha subunits. G proteins function in signal transduction from cell surface receptors to intracellular pathways, regulating cell functions. G protein alpha subunits bind to guanine nucleotides and are active when bound to GTP but inactive when bound to GDP. Active G12 alpha subunit interacts with ARHGEF1, ARHGEF11, and ARHGEF12, activating the Rho small GTPases and regulating the actin cytoskeleton. GNA13 interacts with AKAP3, RIC8A, and Radixin. Mutations in GNA13 have been linked to diffuse large B-cell lymphoma.
Guanine nucleotide-binding proteins (G proteins) act as modulators or transducers in various transmembrane signaling systems. GNA13 activates RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF, and ARHGEF12/LARG). GNA13-dependent Rho signaling regulates the transcription factor AP-1. GNA13 promotes tumor cell invasion and metastasis by activating the RhoA/ROCK signaling pathway. GNA13 inhibits CDH1-mediated cell adhesion independently of Rho activation.
GNA13 is also known as G13, HG1N.
