GMCL1
GMCL1: The Master Regulator of Cell Death and Disease
Description
Glycoprotein M6A (GMCL1) is a multifunctional protein that plays a pivotal role in regulating cell death and disease pathogenesis. It is primarily localized to the mitochondrial outer membrane, where it exerts its diverse biological functions. GMCL1 contains two transmembrane domains, flanked by an N-terminal cytoplasmic domain and a C-terminal intermembrane domain.
Associated Diseases
Genetic alterations and dysregulation of GMCL1 have been implicated in the development and progression of various diseases, including:
- Cancer: Altered GMCL1 expression and mutations have been linked to the initiation and progression of several types of cancer, including breast, lung, and colon cancer.
- Neurodegenerative diseases: GMCL1 dysfunction has been implicated in the pathogenesis of Alzheimer's and Parkinson's diseases.
- Autoimmune diseases: GMCL1 plays a role in regulating immune responses, and its abnormalities have been associated with autoimmune conditions such as lupus and rheumatoid arthritis.
- Cardiovascular diseases: GMCL1 regulates mitochondrial function and cell death in the heart, and its dysregulation has been linked to heart failure and myocardial infarction.
Did you Know ?
GMCL1 deficiency has been shown to protect mice against experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. This finding suggests that GMCL1 inhibition could be a potential therapeutic target for autoimmune diseases.
