GLYAT
Description
The GLYAT (glycine-N-acyltransferase) is a protein-coding gene located on chromosome 11.
Glycine-N-acyltransferase, also known as GLYAT, is an enzyme encoded by the GLYAT gene in humans. This enzyme is primarily found in the liver and kidneys, where it conjugates glycine with acyl-CoA substrates within the mitochondria. GLYAT plays a crucial role in detoxifying a wide range of xenobiotic and endogenous metabolites, including benzoic acid (found in fruits, vegetables, and used as a preservative in medicine and foodstuffs), salicylic acid (a metabolite of aspirin), and various endogenous metabolites. The diversity of substrates is evident in the variety of acylglycines excreted in the urine of patients with organic acid metabolism defects. While no defect in glycine N-acyltransferase has been identified yet, there is significant variation in glycine conjugation capacity among individuals. Human glycine N-acyltransferase isoform a is a protein consisting of 296 amino acids, translated from mRNA transcript splice variant 1. It is encoded by exons 2 to 6 of the mRNA transcript. The literature reports the molecular weight to be approximately 30 kDa or 27 kDa, with a predicted size of 33.9 kDa.
GLYAT is also known as ACGNAT, CAT, GAT.
