GLTSCR1
Glioblastoma (GBM): The Deadly Assault on the Brain
Description:
Glioblastoma (GBM) is the most aggressive and lethal primary brain tumor, originating from the glial cells that support neurons. It is characterized by rapid growth, high invasiveness, and resilience to treatment. GBM tumors are typically located in the cerebral hemispheres, with a median age of diagnosis in the 50s and 60s.
Associated Diseases:
Certain genetic and environmental factors are linked to an increased risk of developing GBM. Associated diseases include:
- Neurofibromatosis Type 1: A genetic disorder that predisposes individuals to GBM formation.
- Li-Fraumeni Syndrome: A cancer predisposition syndrome that includes GBM as a potential malignancy.
- Radiation Exposure: High doses of radiation exposure, such as that received during cancer treatment, can increase the risk of GBM decades later.
Did you Know ?
In the United States, GBM accounts for approximately 16% of all brain tumors and is the most common malignant brain tumor. The median survival time for patients with GBM is less than two years, highlighting the urgent need for effective treatments.
