GLO1
Description
The GLO1 (glyoxalase I) is a protein-coding gene located on chromosome 6.
GLO1 (Glyoxalase I) is an enzyme that catalyzes the first step in the glyoxalase system, a detoxification pathway for methylglyoxal, a toxic byproduct of normal metabolism. The enzyme converts hemithioacetal adducts, formed from methylglyoxal and glutathione, to S-lactoylglutathione. This reaction is important for protecting cells from the damaging effects of methylglyoxal. GLO1 is also involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B and is required for normal osteoclastogenesis. GLO1 is an attractive target for drug development due to its role in parasitic protozoa and cancer.
GLO1 catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:9705294, PubMed:23122816). It is involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (PubMed:19199007) and is required for normal osteoclastogenesis (By similarity).
GLO1 is also known as GLOD1, GLYI, HEL-S-74.
Associated Diseases
- schizophrenia
- Ehlers-Danlos syndrome, musculocontractural type
- urinary bladder carcinoma
- cancer
- hyperinsulinism due to INSR deficiency
- breast cancer
- hyperinsulinism due to glucokinase deficiency
- type 1 diabetes mellitus
- exercise-induced hyperinsulinism
