GLIPR1
Description
The GLIPR1 (GLI pathogenesis related 1) is a protein-coding gene located on chromosome 12.
GLIPR1 is a protein that is found in humans and is encoded by the GLIPR1 gene. It has similarities to two protein families: the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. GLIPR1 was first discovered in human glioblastoma, and it is also a marker of myelomocytic differentiation in macrophages. This means that it helps to guide the development of these types of immune cells.
GLIPR1 has two different forms, each with a different number of amino acids. Both forms contain two important domains: SCP (SCP-like extracellular protein domain) and CAP (Cysteine-rich secretory protein family). These domains are involved in various cellular processes, and the transmembrane domain in GLIPR1 is unique to mammalian CAP proteins.
GLIPR1 is linked to tumor suppression, specifically through its interaction with the p53 tumor suppressor gene. The p53 gene is a crucial regulator of cell growth and is frequently mutated in cancer. Mutations in p53 can lead to uncontrolled cell growth and spread (metastasis). The discovery of GLIPR1 as a p53 target gene highlighted its potential role in preventing tumor development.
GLIPR1 plays a role in cellular differentiation, particularly in macrophages. It is also involved in tumor suppression, potentially acting as a target of the p53 tumor suppressor gene.
GLIPR1 is also known as CRISP7, GLIPR, RTVP1.
