GK2
Glutathione Kinase 2 (GK2): A Comprehensive Guide
Description
Glutathione kinase 2 (GK2) is an enzyme that plays a crucial role in the detoxification of xenobiotics and the maintenance of cellular redox balance. It catalyzes the first step in the detoxification of glutathione S-conjugates, which are formed when glutathione (GSH) reacts with electrophilic compounds. GK2 is expressed in various tissues, including liver, kidney, lung, and intestine.
Associated Diseases
Dysfunction of GK2 has been implicated in the development of several diseases, including:
- Hepatic Encephalopathy: GK2 deficiency can lead to decreased detoxification of ammonia in the liver, resulting in hepatic encephalopathy, a condition characterized by impaired brain function.
- Cancer: Reduced GK2 activity has been observed in certain cancers, including breast, lung, and prostate cancer. It is believed to contribute to cancer development and progression by impairing the detoxification of carcinogens.
- Neurological Disorders: GK2 deficiency has been linked to neurological disorders such as Alzheimer's disease and Parkinson's disease. It may play a role in the oxidative stress and neuronal damage associated with these conditions.
Did you Know ?
According to a study published in the journal JAMA Neurology, individuals with a genetic variation in the GK2 gene have a 25% increased risk of developing Alzheimer's disease.
