GIPC1
Title: GIPC1: A Versatile Protein with Complex Roles in Human Health
Description
GIPC1 (GAIP-interacting protein, C-terminus) is a multifaceted protein that plays diverse roles in cellular processes. It exists in two primary isoforms, GIPC1A and GIPC1B, each with distinct functions and tissue distributions. GIPC1 is primarily a scaffold protein that interacts with multiple partners to form signaling complexes, regulating a wide range of cellular functions, including cytoskeletal dynamics, membrane trafficking, and cell polarity.
Associated Diseases
Dysregulation of GIPC1 has been implicated in various human diseases, particularly those related to neurological function and cancer:
- Neurodegenerative diseases: Mutations in GIPC1 have been linked to familial intellectual disability and autism spectrum disorders. GIPC1 plays a crucial role in neuronal development and synaptic plasticity.
- Cancer: GIPC1 is often overexpressed in cancer cells, where it contributes to increased cell proliferation, migration, and metastasis. It is associated with poorer prognosis in several types of cancer, including lung, breast, and prostate cancer.
Did you Know ?
- GIPC1 interacts with over 100 different binding partners, making it one of the most promiscuous scaffold proteins known. This extensive network enables it to influence a wide range of cellular pathways.
