GINS4

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Description

The GINS4 (GINS complex subunit 4) is a protein-coding gene located on chromosome 8.

GINS4 is essential for the proper function of the GINS complex, which is crucial for initiating DNA replication and advancing replication forks. The GINS complex is a central component of the CDC45-MCM-GINS (CMG) helicase, the molecular machinery responsible for unwinding template DNA during replication. This unwinding process forms the foundation for the replisome, the complex of proteins involved in DNA replication.

GINS4 is also known as SLD5.

Associated Diseases

• endometrial cancer
• cancer
• urinary bladder carcinoma
• X-linked retinal dysplasia
• retinitis pigmentosa
• nanophthalmia
• severe early-childhood-onset retinal dystrophy
• retinal degeneration-nanophthalmos-glaucoma syndrome
• premature ovarian failure 12
• X-linked retinoschisis
• exudative vitreoretinopathy 2, X-linked
• microphthalmia, isolated, with coloboma 7
• microphthalmia, isolated, with coloboma 10