GFRAL


Description

The GFRAL (GDNF family receptor alpha like) is a protein-coding gene located on chromosome 6.

GFRAL is a protein that in humans is encoded by the GFRAL gene.

GFRAL is a brainstem-restricted receptor for GDF15 that plays a crucial role in regulating food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stresses. Upon binding to its ligand, GDF15, GFRAL interacts with RET, a tyrosine kinase receptor, leading to the activation of MAPK- and AKT- signaling pathways.

GFRAL is also known as C6orf144, GRAL, UNQ9356, bA360D14.1.

Associated Diseases



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