GFRA4
Description
The GFRA4 (GDNF family receptor alpha 4) is a protein-coding gene located on chromosome 20.
GFRα4, also known as the persephin receptor, is a protein encoded by the GFRA4 gene in humans.
GFRα4 is a receptor for the protein persephin. It plays a role in activating the RET receptor through GDNF-induced autophosphorylation. GFRα4 is potentially crucial for the development of C-cells and the adrenal medulla after birth.
Associated Diseases
- arthrogryposis multiplex congenita
- fetal akinesia deformation sequence 1
- fetal akinesia deformation sequence
- thyroid hormone metabolism, abnormal, 3
- thyroid hormone metabolism, abnormal 1
- familial thyroid dyshormonogenesis
- selective pituitary resistance to thyroid hormone
- glycogen storage disease due to glycogen branching enzyme deficiency
- melorheostosis
- autosomal recessive hypophosphatemic rickets
- hypothyroidism, congenital, nongoitrous
- hypothyroidism due to TSH receptor mutations
- hypothyroidism, congenital, nongoitrous, 5
- X-linked central congenital hypothyroidism with late-onset testicular enlargement
- generalized resistance to thyroid hormone
- familial gestational hyperthyroidism
