GFRA4

---

Description

The GFRA4 (GDNF family receptor alpha 4) is a protein-coding gene located on chromosome 20.

GFRα4, also known as the persephin receptor, is a protein encoded by the GFRA4 gene in humans.

GFRα4 is a receptor for the protein persephin. It plays a role in activating the RET receptor through GDNF-induced autophosphorylation. GFRα4 is potentially crucial for the development of C-cells and the adrenal medulla after birth.

Associated Diseases

• arthrogryposis multiplex congenita
• fetal akinesia deformation sequence 1
• fetal akinesia deformation sequence
• thyroid hormone metabolism, abnormal, 3
• thyroid hormone metabolism, abnormal 1
• familial thyroid dyshormonogenesis
• selective pituitary resistance to thyroid hormone
• glycogen storage disease due to glycogen branching enzyme deficiency
• melorheostosis
• autosomal recessive hypophosphatemic rickets
• hypothyroidism, congenital, nongoitrous
• hypothyroidism due to TSH receptor mutations
• hypothyroidism, congenital, nongoitrous, 5
• X-linked central congenital hypothyroidism with late-onset testicular enlargement
• generalized resistance to thyroid hormone
• familial gestational hyperthyroidism