Voriconazole
Voriconazole, a triazole antifungal medication, is used to treat invasive fungal infections like aspergillosis and candidiasis.
Impact of Gene Variants
Genetic variations in genes encoding drug-metabolizing enzymes, particularly CYP2C19, can influence voriconazole metabolism and plasma concentrations. Poor metabolizers may experience increased drug levels and a higher risk of adverse effects, while ultra-rapid metabolizers may have decreased efficacy.
Ways to Recognize Problems
Monitoring voriconazole plasma concentrations is crucial to ensure therapeutic efficacy and prevent toxicity. Individuals with genetic variations in CYP2C19 may require dose adjustments based on genotype and plasma concentration measurements. Common adverse effects include visual disturbances, hepatotoxicity, and neurological symptoms.
Ways to Improve
Tailoring voriconazole dosing based on genetic testing results and therapeutic drug monitoring helps optimize treatment outcomes and minimize the risk of adverse effects. Healthcare providers should consider individual factors such as genotype, drug interactions, and renal function when prescribing voriconazole.
Did you know
Variants in the CYP2C19 gene can lead to a tenfold difference in voriconazole plasma levels.
