Anterior Cruciate Ligament Rupture - ACL

The Anterior Cruciate Ligament (ACL) is a key structure in the knee joint, resisting anterior tibial translation and rotational loads. An ACL rupture is a partial or complete tear of this ligament, causing knee pain, swelling, and hampered leg movement.

Impact of Gene Variants

Genetic factors play a significant role in ACL ruptures. Studies have shown a familial predisposition for ACL rupture and have identified correlations between ACL rupture and different genetic variations. Variations in genes involved in the structure of type 1 collagen are particularly prominent.

Ways to Recognize Problems

Symptoms of an ACL rupture include a pop sound in the knee, a popping sensation, swelling and pain within a few hours of injury, loss of range of motion, severe pain causing hindrance in continuing the activity, and tenderness and discomfort around the joint while walking.


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Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.