Acetaminophen Paracetamol

Acetaminophen, also known as paracetamol, is a widely used medication that helps to ease pain and reduce fever. It is found in over 600 different over-the-counter and prescription medications.

Impact of Gene Variants

Genetic variations, particularly in the UGT1A and CYP2E1 genes, can influence how acetaminophen is metabolized in the body. For instance, UGT1A gene variants can modify acetaminophen pharmacokinetics, and DNA methylation of CYP2E1 may regulate acetaminophen levels in newborns.

Ways to Recognize Problems

Overdose of acetaminophen can lead to symptoms such as loss of appetite, nausea, vomiting, or pain in the upper right side of the abdomen. Immediate medical attention is required if these symptoms are observed.

Ways to Improve

N-acetylcysteine (NAC) is an effective antidote for acetaminophen overdose when administered early. It replenishes glutathione (GSH), which can scavenge the reactive metabolite of acetaminophen.

Did you know

More than 50 million Americans use a medicine that contains acetaminophen each week. Also, a 2016 study found that acetaminophen not only dulls your pain, but also dulls your ability to empathize.

Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.