Acetaminophen Paracetamol
Acetaminophen, also known as paracetamol, is a widely used medication that helps to ease pain and reduce fever. It is found in over 600 different over-the-counter and prescription medications.
Impact of Gene Variants
Genetic variations, particularly in the UGT1A and CYP2E1 genes, can influence how acetaminophen is metabolized in the body. For instance, UGT1A gene variants can modify acetaminophen pharmacokinetics, and DNA methylation of CYP2E1 may regulate acetaminophen levels in newborns.
Ways to Recognize Problems
Overdose of acetaminophen can lead to symptoms such as loss of appetite, nausea, vomiting, or pain in the upper right side of the abdomen. Immediate medical attention is required if these symptoms are observed.
Ways to Improve
N-acetylcysteine (NAC) is an effective antidote for acetaminophen overdose when administered early. It replenishes glutathione (GSH), which can scavenge the reactive metabolite of acetaminophen.
Did you know
More than 50 million Americans use a medicine that contains acetaminophen each week. Also, a 2016 study found that acetaminophen not only dulls your pain, but also dulls your ability to empathize.
