Enflurane
Enflurane is a halogenated ether used primarily as an inhalational anesthetic. It belongs to the family of volatile liquid anesthetics that are administered via inhalation to induce and maintain anesthesia during surgical procedures. Enflurane acts by depressing the central nervous system, leading to loss of consciousness and pain sensation in patients undergoing surgery. While it has been widely used in the past, its popularity has declined in recent years due to concerns over its side effects and the introduction of newer anesthetic agents. However, it still plays a role in certain medical settings where other options may not be suitable.
Impact of Gene Variant
Research into the impact of gene variants on enflurane metabolism and response is limited compared to other drugs. However, variations in genes encoding enzymes involved in drug metabolism, such as cytochrome P450 enzymes, may influence individual responses to enflurane. For example, genetic polymorphisms in the CYP2E1 gene, which encodes the enzyme primarily responsible for enflurane metabolism, could affect the rate at which the drug is broken down in the body. This, in turn, may influence factors such as the duration and depth of anesthesia achieved with enflurane.
Ways to Recognize Problems
Recognizing problems associated with enflurane anesthesia requires close monitoring of patients during and after surgery. Some common signs and symptoms that may indicate issues with enflurane anesthesia include:
