ZWINT
Description
The ZWINT (ZW10 interacting kinetochore protein) is a protein-coding gene located on chromosome 10.
ZWINT, or ZW10 interactor (Zwint-1), is a protein encoded by the ZWINT gene in humans. It is involved in kinetochore function, although its precise role is not fully understood. ZWINT interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. ZWINT localizes to prophase kinetochores before ZW10, remaining detectable on the kinetochore until late anaphase. It exhibits a uniform distribution in the cytoplasm of interphase cells. Different isoforms of ZWINT have been identified due to alternative splicing. ZWINT has been shown to interact with MIS12 and RAB3C.
ZWINT is a component of the MIS12 complex, which plays a crucial role in kinetochore formation and spindle checkpoint activity. ZWINT is essential for directing ZW10 to the kinetochore during prometaphase.
ZWINT is also known as HZwint-1, KNTC2AP, SIP30, ZWINT1.
Associated Diseases
- breast cancer
- schizophrenia 15
- pachyonychia congenita
- Phelan-McDermid syndrome
- cancer
- Potocki-Lupski syndrome
- Smith-Magenis syndrome
- intellectual developmental disorder, X-linked, syndromic, Pilorge type
