ZW10
Description
The ZW10 (zw10 kinetochore protein) is a protein-coding gene located on chromosome 11.
ZW10, encoded by the ZW10 gene, is a crucial protein involved in ensuring accurate chromosome segregation during cell division. It binds to centromeres during early cell division stages and to kinetochore microtubules during metaphase. ZW10 is also involved in non-dividing cells, playing a role in targeting cytoplasmic dynein and dynactin to the Golgi and other membranes, as well as in SNARE-mediated ER-Golgi trafficking. It is essential for the mitotic checkpoint, preventing premature cell division and ensuring proper chromosome alignment. ZW10‘s function is linked to its association with specific protein complexes, including the RZZ complex in mitosis and the NRZ complex in interphase.
ZW10 is essential for the mitotic checkpoint, preventing premature exit from mitosis. It facilitates the assembly of dynein-dynactin and MAD1-MAD2 complexes onto kinetochores, crucial for proper chromosome segregation. Its spindle assembly function is linked to its presence in the mitotic RZZ complex. ZW10 also plays a role in membrane traffic between the Golgi and endoplasmic reticulum (ER), likely through its association with the interphase NRZ complex, involved in SNARE assembly at the ER.
ZW10 is also known as HZW10, KNTC1AP.
