ZSCAN10
Description
The ZSCAN10 (zinc finger and SCAN domain containing 10) is a protein-coding gene located on chromosome 16.
ZSCAN10 is a crucial transcription factor specifically found in embryonic stem (ES) cells. It plays a vital role in maintaining the pluripotency of ES cells, allowing them to differentiate into any cell type. ZSCAN10 can either activate or repress the expression of target genes depending on the specific cellular context. It binds to a specific DNA sequence, 5‘-[GA]CGCNNGCG[CT]-3‘, and directly regulates the expression of other important genes involved in ES cell pluripotency, such as POU5F1/OCT4, ZSCAN4, and ALYREF/THOC4.
ZSCAN10 is also known as ZFP206, ZNF206.
Associated Diseases
- retinitis pigmentosa
- X-linked retinal dysplasia
- severe early-childhood-onset retinal dystrophy
- reticular dystrophy of the retinal pigment epithelium
- choroidal dystrophy, central areolar, 1
- age related macular degeneration 4
- age related macular degeneration 7
- age related macular degeneration 11
- coloboma of macula
- X-linked retinoschisis
- coloboma of optic nerve
