ZPBP
The ZPB2 Gene: Its Role in Health and Disease
Introduction
The ZPB2 gene, also known as the zona pellucida glycoprotein B2 gene, plays a crucial role in human reproduction, fertilization, and early embryonic development. In this comprehensive guide, we will explore the ZPB2 gene, its function, associated diseases, and the latest research advancements.
Description
The ZPB2 gene is located on chromosome 1 and codes for a protein that is present in the zona pellucida, the protective layer that surrounds mammalian eggs. The zona pellucida facilitates fertilization by interacting with sperm, allowing only compatible sperm to penetrate the egg.
Associated Diseases
Mutations or variations in the ZPB2 gene have been linked to several reproductive disorders, including:
- Infertility: Mutations in ZPB2 can impair sperm binding and fertilization, leading to infertility in both men and women.
- Miscarriage: Some ZPB2 mutations have been associated with an increased risk of miscarriage.
- Abnormal Embryonic Development: ZPB2 plays a role in early embryonic development and mutations in this gene can lead to developmental abnormalities in the fetus.
Did you Know ?
- Studies have shown that mutations in ZPB2 are found in approximately 1-2% of infertile couples.
