ZNF865
Description
The ZNF865 (zinc finger protein 865) is a protein-coding gene located on chromosome 19.
ZNF865, also known as BLST, is a protein belonging to the zinc finger family. It features 20 zinc finger domains, disordered regions, transactivation domains, and TGEKP domains. ZNF865 is linked to Parkinson‘s disease, esophageal cancer, and musculoskeletal disorders. Its absence is associated with an increased risk of Parkinson‘s disease, poorer outcomes in esophageal cancer, and a higher incidence of musculoskeletal problems. ZNF865 is found in various human cell and tissue types. Bioinformatics suggests it‘s localized to the nucleus and plays a role in metal ion binding, DNA-binding transcription factor activity, interaction with RNA polymerase II, and transcription regulation. Experimental evidence shows that ZNF865 regulates cellular senescence, cell cycle progression, DNA replication, DNA repair, and protein processing. Lack of ZNF865 expression triggers cellular senescence, highlighting its importance for healthy cell function. Increased ZNF865 expression leads to cell cycle shifts, increased DNA replication, and higher proliferation rates. Overall, ZNF865 is a confirmed regulator of cellular senescence, cell cycle progression, and DNA replication.
ZNF865 is also known as -.
