ZNF839
Description
The ZNF839 (zinc finger protein 839) is a protein-coding gene located on chromosome 14.
ZNF839, or zinc finger protein 839, is a protein encoded by the ZNF839 gene in humans. Located on the long arm of chromosome 14, it is implicated in the humoral immune response against cancer, specifically renal carcinoma, due to its overexpression in cancer patients, particularly those with renal carcinoma. ZNF839 functions in transcription regulation through metal-ion binding, utilizing its C2H2-type zinc finger repeats to bind to DNA. The human ZNF839 gene spans 25,326 nucleotides and encodes the longest isoform, transcript variant 1. Located at 14q32.31 on the plus strand, the gene comprises 8 exons, one zinc finger repeat, and 3 disordered regions. Transcript variant 2 lacks exon 1, starting at a downstream codon. The mRNA isoform 1 encoded by the human ZNF839 gene has a length of 2992 nucleotides.
ZNF839 is also known as C14orf131.
